By Richard Prayson MD, Bette K. Kleinschmidt-DeMasters MD, Mark Cohen MD, David Elder MB ChB
"The advisor Pathology" sequence is designed to disseminate the information of professional surgical pathology specialists within the research and prognosis of inauspicious situations to the complete neighborhood of pathology practitioners. The volumes are according to genuine consultations and offered in a structure that illustrates the expert's strategy of comparing the case, together with symptoms for session, the consultant's findings and remark, and dialogue of the entity that amplifies the case description. each one quantity within the "Consultant Pathology" sequence is authored via overseas specialists with broad case event within the components lined. Surgical neuropathology is a difficult enviornment for lots of pathologists, due largely to a relative loss of adventure of so much pathologists during this zone in comparison to different components of surgical pathology.
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Extra info for Brain Tumors (Consultant Pathology)
Mueller W, Lass U, Herms J, Kuchelmeister, et al. Clinical analysis in glioblastoma with epithelial differentiation. Brain Pathol 2001;11:39–43. 3. Rosenblum MK, Erlandson RA, Budzilovich GN. The lipid-rich epithelioid glioblastoma. Am J Surg Pathol 1991;15:925–34. Case 15: Gliomatosis Cerebri C L I N I C A L I N F O R M AT I O N We consider the lesion to be an astrocytoma and characterize it as follows: Right Frontal Lobe and Corpus Callosum, Biopsies—Gliomatosis Cerebri, WHO Grade III. The patient is a 42-year-old male who presents with seizures and increased lethargy.
Geddes JF, Thom M, Robinson SFD, et al. Granular cell change in astrocytic tumors. Am J Surg Pathol 1996;20:55–63. 4. Melaragno MJ, Prayson RA, Murphy MA, et al. Anaplastic astrocytoma with granular cell differentiation: case report and review of the literature. Hum Pathol 1993;24:805–8. 7 Focal necrosis is present in the tumor. Case 10: Giant Cell Glioblastoma C L I N I C A L I N F O R M AT I O N cytoplasm. Occasional blood vessels show perivascular chronic inﬂammation, consisting primarily of benignappearing lymphoid cells.
Rare mitotic ﬁgures are observed. 1 Low magniﬁcation appearance of the tumor shows less cellular, neuropil-like islands, arranged against the background of an inﬁltrating astrocytoma. 2 Higher magniﬁcation shows well-circumscribed neuropil island in the background of a ﬁbrillary astrocytoma. 16 17 CASE 6: GLIONEURONAL TUMO R WITH NEUROPIL-LIKE ISLANDS COMMENT DISCUSSION In the most recent WHO Classiﬁcation of Tumours of the Central Nervous System, the glioneuronal tumor with neuropil-like islands is considered a variant of diffuse or ﬁbrillary astrocytoma.