By Prof. Dr. Gisela Dallenbach-Hellweg, Prof. Dr. Dr. h.c. Dietmar Schmidt, Dr. Friederike Dallenbach (auth.)
This new version differs from the previous ones in that there was large revision of so much chapters. fresh advances in study won by means of immunohistochemical, molecular organic, and cytogenetic equipment are integrated, so far as they're appropriate for day-by-day diagnostic paintings. The bankruptcy on neoplasms, specifically, has been vastly elevated in line with the hot WHO foreign Histological type of genital tract tumors, masking all pertinent differential diagnostic facets. The bankruptcy on malignant lymphomas and hematopoetic neoplasms related to the endometrium is a brand new contribution to this variation (F. D. , Ulm). we have now revised the bankruptcy on gestational illnesses, incorpor- ing fresh advances within the differential analysis of gestational trophoblastic tumors. New discoveries and reviews in correlating constitution and serve as in infertility and in h- mone substitute treatment of peri- and postmenopausal sufferers also are integrated. Many new microphotographs were further to demonstrate the advances in tumor learn and in immunohistochemical detection tools. we've got up to date the record of references together with fresh proper courses. To the correspondents and specialists who've contributed worthwhile observations and proposals, bringing thereby to our cognizance omissions within the moment variation, we recognize our cordial thank you. We thank Dr. Wolfram Klapper, Director of the L- phom check in of the collage of Kiel, for case fabric for making the micropho- photograph illustrations of lymphomas. the employees of Springer-Verlag has earned our gratitude for his or her ability in getting ready this new edition.
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Extra info for Atlas of Endometrial Histopathology
Distinction is possible by correlation with the functional diagnosis of the endometrium and by the clinical history. 3 Papillary (Syncytial) Metaplasia Papillary or syncytial epithelial projections with hyperchromatic nuclei may develop focally on the surface (Fig. 5) or in the glandular epithelium (Fig. 6) most often in postmenopausal women following bleeding or mechanical irritation. Morphologic Differential Diagnosis. If such metaplastic foci arise from larger areas, they must be differentiated from early serous papillary carcinoma, which possesses polymorphic nuclei and fibrovascular cores not shown by benign metaplasia.
56) shows slight underdevelopment of some of the glands; these are poorly convoluted and lined by a low, cuboidal, rather inactive epithelium with dense, small nuclei, whereas the epithelium of neighboring glands is normally differentiated according to the day of the cycle. The general height of the endometrium varies slightly from one region to another. In the lower layers, the stroma may be poorly differentiated. Clinical Possibilities. (a) Proliferative or secretory phase with climacteric variations; (b) a very early stage of irregular proliferation or deficient or irregular secretion if the patient is below age 40.
35). All transitional stages are encountered, from a few small nodules to extensive metaplasia, which may also involve the surface epithelium (ichthyosis). When the surface epithelium becomes involved (Fig. 1), there is no sharp line of distinction between extensive squamous metaplasia and ichthyosis. The squamous epithelium may be well differentiated, resembling either mature or metaplastic squamous epithelium of the ectocervix, or be immature as morules with scant cytoplasm and poorly delineated cytoplasmic borders, as seen in reserve cell hyperplasia of the endocervical glands.